New simplified molecular design for functional T cell receptor
نویسندگان
چکیده
منابع مشابه
New simplified molecular design for functional T cell receptor.
We have produced a chimeric single-chain T cell receptor (TcR) that combines the specific antibody recognition function and TcR/CD3 signaling properties within the same polypeptide chain. This hybrid molecule consisted of a single-chain antibody combining site that was connected over a short spacer to the transmembrane and cytoplasmic region of CD3 zeta. When expressed on TcR- or TcR+ T cell hy...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 1993
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.1830230705